News & Publications
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Publications
Tissue plasminogen activator…..
May, 2023
Kumar S, Shah S, Tang HM, Smith M, Borrás T, Danias J. Tissue plasminogen activator in trabecular meshwork attenuates steroid induced outflow resistance in mice. PLoS One. 2013 Aug 19;8(8):e72447 Administration of an Adenoviral vector(AdV) carrying PLAT (the gene that encodes for tPA) leads to restoration of outflow facility when expressed in the trabecular meshwork of steroid-induced glaucomatous mice
May, 2023
Gindina S, Hu Y, Barron AO, Qureshi Z, Danias J.Tissue plasminogen activator attenuates outflow facility reduction in mouse model of juvenile open angle glaucoma. Exp Eye Res. 2020 Oct;199:108179.
o Administration of either tPA or an enzymatically-inactive form of tPA partially reverse the outflow facility reduction in myocilin transgenic mutant mice
May, 2023
Gindina S, Barron AO, Hu Y, Dimopoulos A, Danias J. Tissue plasminogen activator rescues steroid-induced outflow facility reduction via non-enzymatic action. Mol Vis. 2021 Dec 7;27:691-705. eCollection 2021.tPA also has an effect on outflow facility via non-enzymatic activity
Outflow facility does not increase further in healthy normal strain mice treated with tPA
- Kumar S, Shah S, Tang HM, Smith M, Borrás T, Danias J. Tissue plasminogen activator in trabecular meshwork attenuates steroid induced outflow resistance in mice. PLoS One. 2013 Aug 19;8(8):e72447
- Administration of an Adenoviral vector(AdV) carrying PLAT (the gene that encodes for tPA) leads to restoration of outflow facility when expressed in the trabecular meshwork of steroid-induced glaucomatous mice
- Administration of either tPA or an enzymatically-inactive form of tPA partially reverse the outflow facility reduction in myocilin transgenic mutant mice
- tPA also has an effect on outflow facility via non-enzymatic activity
- Outflow facility does not increase further in healthy normal strain mice treated with tPA
Gerometta R, Kumar S, Shah S, Alvarez L, Candia O, Danias J. Reduction of steroid-induced intraocular pressure elevation in sheep by tissue plasminogen activator. Invest Ophthalmol Vis Sci 2013;54:7903-7909.